TAURINE SUPPLEMENTATION NORMALIZES SKELETAL MUSCLE FUNCTIONS IN TYPE 2 DIABETES RATS

TAURINE SUPPLEMENTATION NORMALIZES SKELETAL MUSCLE FUNCTIONS IN TYPE 2 DIABETES RATS

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Objective: To study effect of supplementation of taurine on force frequency relationship and fatigue of rodent skeletal muscles in type 2 diabetes mellitus.Study Design: Laboratory-based experimental study.Place and Duration of custom congratulations banner Study: Department of Physiology at Army Medical College Rawalpindi, from Apr 2013 to Jun 2013.Methodology: Ninety Sprague-Dawley rats were divided randomly in to 3 groups; control (group-1), beta-alanine (group-2), and taurine group (group-3).

All rats were fed with taurine free-high fat diet and administered streptozocin to induce type 2 diabetes mellitus.In addition, group-1 was supplemented with 0.02% (w/v) taurine, group-2 with 3% (w/v) beta-alanine, and group-3 with 3% (w/v) taurine in their respective drinking water.At 21st day, plasma glucose and insulin resistance were measured to affirm type-II diabetes mellitus in all groups.

At 28th day, contractile functions of extensor digitorum longus muscles at high frequencies were evaluated using i Worx data acquisition unit (AHK/214).Results: The decline in maximum fused tetanic tension, maximum fused tetanic tension after fatigue protocol, and hobbit door for sale recovery from fatigue was significantly ameliorated in taurine supplemented diabetic rats.Conclusion: Taurine supplementation significantly improved the contractile functions of diabetic rodent skeletal muscle at high frequency stimulation.